Chairs: R. Hohlfeld, U. Bogdahn

Invited Speaker: Nancy J. Rothwell, Manchester

Neuro-immune responses in neurodegeneration: role of IL-1 in stroke

Selected oral presentations

15:10 – 15:25 H.O.Besedovsky, D. Balschun, F. Pitossi, H. Schneider, W. Zuschratter, A. Del Rey; MARBURG, MAGDEBURG, BUENOS AIRES

Endogenous IL-6 modulates the consolidation of hippocampal LTP

15:25 – 15:40 M. Gottschalk, T. Kümpfel, A. Yassouridis, F. Holsboer, F. Weber; MUNICH

Fatigue and regulation of the hypothalamo-pituitary-adrenal axis (HPA axis) in multiple sclerosis (MS)

15:40 – 15:55 K. Haerter, A. Vroon, A. Kavelaars, V. Limmroth, C.J. Heijnen, M. Schedlowski, S. Elsenbruch; ESSEN; UTRECHT

Adrenergic modulation of cytokine production during MOG-induced EAE

15:55 – 16:10 C. Körner, B. Wieland, W. Richter, H.-M. Meinck; HEIDELBERG

Stiff man-syndrome, a neuropsychiatric disorder with autoimmunity against GABAergic neurones. Part II: GAD autoantibodies impair GABAergic functions within the motor cortex

16:10 – 16:25 H. Neumann; GÖTTINGEN

Selective attack of MHC class I-induced neuritis by cytotoxic T lymphocytes

16:25 – 16:40 E. Weihe, C. Depboylu, L.E. Eiden; MARBURG; BETHESDA

Responses of neuronal, glial, and endothelial cell compartments of the brain to lentiviral infection an effects of antiretroviral treatment: A new conceptualisation of Neuro-AIDS

16:40 Coffee – Break

Chairs: T. Pollmächer, M.J. Schwarz

Invited Speaker: Volker Arolt, Münster

Psychoneuroimmunology in Clinical Psychiatric Research – Results and Prospects

Selected oral presentations

17:40 – 17:55 B. Fellerhoff, B. Bondy, N. Müller, M. Vogel, B. Laumbacher, R. Wank; MUNICH

HLA factors in families and unrelated patients with psychiatric disorders: significant deviations in recombination frequencies and allelic frequencies of TAP but not LMP alleles

17:55 – 18:10 B.L. Fiebich, B. Müksch, M. Böhringer, M. Hüll; FREIBURG

Neuroinflammatory circuits in Alzheimer's disease: Interleukin-1 induces cyclooxygenase 2 in human neuroblastoma cells

18:10 – 18:25 K.G. Kahl, N Kruse, M H Schmidt, P Rieckmann; MANNHEIM; LÜBECK; WÜRZBURG

Quantitative analysis of cytokine mRNA expression patterns in the disease course of adolescent patients with anorexia nervosa

18:25 – 18:40 M. Peters, M. Rothermundt, N.T. Bui, V. Arolt, J.H.M. Prehn; MÜNSTER

S100B protects against neuronal cell death induced by NMDA or hypoxia

18:40 – 18:55 M. Rothermundt, M Peters, M. Wiesmann, S Rudolf, M Hettich, S. Abel, H. Kirchner, V. Arolt; MÜNSTER; LÜBECK

S100B in schizophrenic psychosis

18:55 – 19:10 M.J. Schwarz, M. Riedel, H. Krönig, S. Chiang, M. Ackenheil, N. Müller; MUNICH

Th1 and Th2 relationship in schizophrenia - immunological, immunogenetic and therapeutic aspects

19:10 – 19:25 S. Sorge, T. Pollmächer, D.M. Lancel; MUNICH

Effects of clozapine on sleep and brain concentration of TNF in rats

19:25 – 19:40 H. Vedder, S. Lanquillon, J.-C. Krieg; MARBURG, REGENSBURG

Regulation of tumor-necrosis factor-alpha production by glucocorticoids in major depression

19:40 Break

Authors will be present at their posters between 20:30 – 21:30 (authors and titles see below)

Chairs: D. Gemsa, C. Heijnen

Invited Speaker: Virginia M. Sanders, Chicago

Molecular mechanisms for neuroimmunomodulation of CD4+ T cell differentiation and function

Selected oral presentations

09:40 – 09:55 T. Brzoska, B. Altmann, T. Scholzen, D.-H. Kalden, A. Schwarz, T. Schwarz, S. Grabbe and T.A. Luger; MÜNSTER

Intravenous injection of the immunomodulator alpha-MSH induces hapten-specific tolerance

09:55 – 10:10 A. Del Rey, A. Kabiersch, E. Roggero, M. Schäfer, E. Weihe, H.O. Besedovsky; MARBURG

Interactions between the immune and the sympathetic nervous system during a genetically-determined autoimmune lymphoproliferative disease

10:10 – 10:25 C.J. Heijnen, M.S. Lombardi, A.Vrooni, R. Jacobs, R.E. Schmidt, M. Schedlowski, A.Kavelaars; UTRECHT; HANNOVER; ESSEN

G protein coupled receptors and neuroendocrine signalling in autoimmunity

10:25 – 10:40 J. Herklotz, J. Westermann; HANNOVER; LÜBECK

Local immune response in the spleen: Regulation by the nervous system and effects on behaviour

10:40 Coffee – Break

11:00 Selected oral presentations

Chairs: R.E Schmidt, J. Westermann

11:00 – 11:15 S. Kerzel, G. Päth, D. Quarcoo, U. Raap, H. Renz; A. Braun; MARBURG; HANNOVER

Neuronal plasticity is mediated by neurotrophin receptor p75NTR in a murine model of allergic bronchial asthma

11:15 – 11:30 J. Kraus, C. Börner, E. Giannini, K. Hickfang, V. Höllt; MAGDEBURG

Mu opioid receptor expression in immune cells is induced by IL-4 and TNF

11:30 – 11:45 M. Levite; TEL AVIV; REHOVOT

Nervous Immunity: Neurotransmitters, through their specific receptors, dictate T-cell functions, in a direct, powerful and contextual manner

11:45 – 12:00 J.R. Stevenson, J. Westermann, S. Supanz, P.M. Liebmann, K. Schauenstein; GRAZ; LÜBECK

Alpha-adrenergic treatment differentially affects expression of adhesion molecules and leads to enhanced lymphocyte apoptosis in lymphoid organs of the rat

12:00 Lunch (with poster viewing session)

Chairs: S. Bornstein, A. Del Rey

Invited Speaker: Samuel M. McCann, Baton Rouge

Neurocontrol of cytokine release

Selected oral presentations

14:40 – 14:55 A. Buske-Kirschbaum, S. Fischbach, W. Rauh, J. Hanker, D.H. Hellhammer; TRIER

Increased responsiveness of the hypothalamus-pituitary-adrenal (HPA) axis to stress in newborns with atopic disposition

14:55 – 15:10 M. Haack, T. Kraus, A. Schuld, M. Dalal, D. Köthe, T. Pollmächer; MUNICH

Diurnal variations of interleukin 6 plasma levels during sleep and wakefulness: effects of particularities of blood drawing

15:10 – 15:25 C. Kirschbaum, L. Joksimovic, N. Rohleder, J. Wolf, S. Riegler; DÜSSELDORF

Posttraumatic stress disorder and HPA functioning: Hypocortisolism and increased glucocorticoid sensitivity of PBMC in Bosnian war victims

15:25 – 15:40 T. Lange, B. Perras, H.L. Fehm, J. Born; LÜBECK

Sleep enhances the human antibody response to hepatitis A vaccination

15:40 – 15:55 I.D. Neumann, S. Krömer, A. Wigger; REGENSBURG; MUNICH

Early life stress affects the emotional and neuroendocrine development of rat offspring in dependence on the innate level of anxiety

15:55 – 16:10 R. Oberbeck, D. Schmitz, M. Schüler, K. Wilsenack, C. Biskup, M. Schedlowski, D. Nast-Kolb, M.S. Exton; ESSEN

Catecholaminergic modulation of cellular immune function and survival during chronic sepsis in the mouse

16:10 Coffee – Break

16:30 Selected oral presentations

Chairs: J. Born, E. Haen

16:30 – 16:45 U. Renner, P. Lohrer, M. Tichomirova, M. Paez Pereda, L. Schaaf, E. Arzt, G.K. Stalla; MUNICH

Expression and role of Toll-receptors in pituitary folliculostellate cells

16:45 – 17:00 K. Ruprecht, V. Hummel, P. Rieckmann; WÜRZBURG

Production of Oncostatin M by human microglia and peripheral blood mononuclear cells: Potential sources of a cytokine with immunomodulatory effects on human cerebral endothelial cells

17:00 – 17:15 A. Volz, A. Ehlers, S. Beck, J. Younger, A. Ziegler; BERLIN; HINXTON

Transcripts of HLA-linked olfactory receptor genes exhibit premature polyadenylation, exon sharing and long-distance alternative splicing

17:15 – 17:30 A. Wölfler, K. Schauenstein, P.M. Liebmann; GRAZ

Pro- and antioxidant effects of melatonin in lymphoid cells

17:30 – 17:45 E. Zeisberger, G. Ross, J. Roth, T. Hübschle, R. Gerstberger, K. Voigt; GIESSEN; BUDEJOVICE; MARBURG

Are fever-inducing immune signals in part transported to the brain by afferent skin nerves?

17:45 – 18:00 C Kohl, T Walch, R Huber, B Widner, A Laich, E Sölder, J Kemmler, H Schröcksnadel, D Fuchs, B Sperner-Unterweger; INNSBRUCK

Changes of tryptophan and kynurenine in the postpartum period

18:00 Break

Chairs: M. Schedlowski, D. von Holst

Invited Speaker: Christopher L. Coe, Madison

When and how much do psychological factors influence immunity ?

Selected oral presentations

09:45 – 10:00 L. Dawils, V. Stefanski; BAYREUTH

Social confrontation and tumor metastasis in male laboratory rats: health consequences of social stress

10:00 – 10:15 F. Eggert; KIEL

Behavioural specificity of MHC-associated olfactory preferences

10:15 – 10:30 M.U. Göbel, Yu Fen Xie, A.E. Trebst, J.F. Steiner, M.S. Exton, S. Freede, A. Canbay, U. Heemann, M.C. Michel, M. Schedlowski; ESSEN

Behaviourally conditioned immunosuppression

10:30 – 10:45 R. Joachim, D. Quarcoo, A. Zenclussen, J. Niess, P. Arck and B.F. Klapp; BERLIN

Stress-induced increment on bronchoalveolar cell count in OVA- sensitised mice is mediated by tachykinin NK1 receptor

10:45 – 11:00 T. Karl, K. Shingu, R. Jacobs, R.E. Schmidt, R. Mentlein, S. Kaiser, N. Sachser, R. Pabst, St. von Hörsten; HANNOVER; KIEL; MÜNSTER

CD26 mutant rats: A model for psychoneuroimmune interactions

11:00 Coffee Break

11:30 Selected oral presentations

Chairs: R. Pabst, K. Schauenstein

11:30 – 11:45 J.M. Kittner, R. Jacobs, C.R. Pawlak, C.J. Heijnen, M. Schedlowski, R.E. Schmidt; HANNOVER; MARBURG; UTRECHT; ESSEN

Effects of adrenaline infusion on immune parameters in rheumatoid arthritis (RA) patients and healthy controls (HC)

11:45 – 12:00 N. Rohleder, J.M. Wolf, C. Kirschbaum; DÜSSELDORF

Impact of gender and oral contraceptive use on glucocorticoid sensitivity of pro-inflammatory cytokine production after psychosocial stress

12:00 – 12:15 V. Stefanski, L. Dawils, H. Engler, G. Knopf, S. Kurth, A. Peschel, S. Schulz; BAYREUTH

Effects of psychosocial stress on immune cells in laboratory rats: endocrine und immunological mechanisms

12:15 – 12:30 D. von Holst, F. Uhl and W. Stöhr; BAYREUTH

Love in tree shrews (Tupaia belangeri): proximate causes and physiological consequences

12:30 Future aims of the GEBIN: Interactive discussion

Chairs: The Steering Committee of the GEBIN

13:00 Closing of the congress

A. Alipour, J. Faraji, Y. Jafair, A. Mirrezaie, TEHERAN

1. The effect of video games on children’s cortisol: A new perspective

P. Arck, M. Rose, R. Joachim, J. Niess, M. Hildebrandt, B.F. Klapp; BERLIN

2. PsychoNeuroImmunology: Mission impossible ?

S. Birkmann, A. Schuld, M. Haack, W. Liebetrau, M. Dalal, T. Kraus, T. Pollmächer; MUNICH

4. Immunomodulatory properties of low dose dexamethasone - dose and time-of-day effects

K. Bürger, H. Hampel; MUNICH

6. Expression of the interleukin-6 receptor complex in CSF and brain of patients with Alzheimer's disease and controls

R. Deinzer, B. Waschul, N. Granrath, A. Herforth, R Stiller-Winkler, H. Idel; DÜSSELDORF

9. Stress and periodontitis - current perspectives

K. Dinkel, M. Rickert, G. Möller, J. Adamski, H.-M. Meinck, W. Richter; HEIDELBERG, NEUHERBERG

11. Identification of 17ß-Hydroxysteroid Dehydrogenase Type 4 as a novel 80 kDa Antineuronal Antigen in Stiff-Man-Syndrome

M. Ebrecht, A. Buske-Kirschbaum, S. Kern, C. Kirschbaum, D.H. Hellhammer; TRIER, LONDON, DÜSSELDORF

12. Enhanced catecholaminergic reactivity and lymphocyte redistribution after acute stress in patients with psoriasis

U. Eisel, L. Marchetti, V. Fontaine, M. Klein, K. Pfizenmaier; STUTTGART

14. Neuroprotective Function of TNF is mediated via Akt/PKB signalling pathway

S. Elsenbruch, D. Özcan, A. Lysson, G. Holtmann, M. Schedlowski; ESSEN

15. Neuroendocrine-immune responses to food stimulation in patients with irritable bowel syndrome (IBS) and controls

H. Engler, S. Kurth, S. Hoves, V. Stefanski; BAYREUTH

16. Social stress and immunomodulation: specific role of glucocorticoids and catecholamines

S. Fest, A.C. Zenclussen, H. Lange, C. Weber, B. Klapp, P.C. Arck; BERLIN

18. Downregulation of Th1-markers by progressive muscle relaxation (PMR)

B.L. Fiebich, S. Schleicher, O. Spleiss, M. Czygan, M. Hüll; FREIBURG

20. Neuroinflammatory circuits in Alzheimer’s disease: Prostaglandin E-2 induces astroglial interleukin-6 synthesis independent of cAMP formation

P. Flachenecker, T. Kümpfel, M. Gottschalk, P. Rieckmann, F. Weber, C. Trenkwalder, K.V. Toyka; WÜRZBURG

21. Autonomic dysfunction in patients with multiple sclerosis and fatigue

J. Götze, D. Goldmann, J. Niess, A. Dignass, P. Arck; BERLIN

23. Influence of stress on immune-competent cells in patients suffering from ulcerative colitis

V.V. Grinevich, G.F. Jirikowski; JENA; MOSCOW

25. Magnocellular hypothalamic-neurohypophyseal system under acute inflammation

P. Haake, M.U. Göbel, K. Heberling, S. Elsenbruch, M. Schedlowski, T. Krueger; ESSEN

27. Orgasm-induced circulation of lymphocyte subsets

E. Haen, M. Buchberger, W. Dorsch; REGENSBURG

28. Bronchodilatation by antidepressants in allergen sensitised guinea pigs

P. Hauck, U. Ungethüm, A. Schiffold, C. G. O. Baerwald, M. Wahle, A. Krause; BERLIN; LEIPZIG

30. The suppressive effect of acetylcholine on monocyte activation is mediated by nicotinergic receptors

H. Hutzelmeyer, D. v. Holst; BAYREUTH

33. The critical first year in the life of European wild rabbits (Oryctolagus cuniculus)

R. Jacobs, C.R. Pawlak, E. Mikeska, D. Meyer-Olsoni, M. Martin, C.J.Heijnen, M.Schedlowski, R.E. Schmidt; HANNOVER; UTRECHT; ESSEN

34. SLE and RA patients differ from healthy controls in their cytokine pattern after stress exposure

S. Kastenbauer, U. Ködel, T. Brzoska, TA. Luger, HW Pfister; MUNICH; MÜNSTER

38. Failure of alpha-melanocyte stimulating hormone to attenuate cerebral complications in experimental pneumococcal meningitis

B.C. Kieseier, A. Chan, R. Gold, K.V. Toyka and H.P. Hartung; GRAZ; WÜRZBURG

40. Expression of TNF-converting enzyme in inflammatory demyelination of the peripheral nervous system

D. Köthe, M. Haack, D. Hinze-Selch, Th. Kraus, A. Schuld, Th. Pollmächer; MUNICH

44. Body weight and the plasma levels of leptin and endogenous immune modulators during treatment with carbamazepine

H. Krönig, M. Riedel, M. J. Schwarz, M. Ackenheil, N. Müller; MUNICH

47. Genetic investigations based on immunological findings in schizophrenia

H. Krönig, M. J. Schwarz, M. Riedel, M. Ulmschneider, R. Yolken, N. Müller; MUNICH; BALTIMORE

48. TNF polymorphism G308A may protect from cytomegalovirus infection in schizophrenia

S R. Kunz, A. Steptoe, C. Kirschbaum, M. Marmot; LONDON; DÜSSELDORF

49. Differential effects of psychological stress on IL-6 and IL-1ra responses in women and men from the Whitehall II cohort

S. Lanquillon, I. Reckemeyer, H. Vedder, J.C. Krieg, H. Klein; REGENSBURG; MARBURG

51. Cytokines - immunological link between Major Depressive Disorder (MDD) and alcohol abuse?

V.I. Leussink, B. Badent, S. Veit, B. Olshausen, G. Becker, M. Flentje, B. Allolio, W Arlt; WÜRZBURG; HOMBURG

52. Time-dependant endocrine dysfunction and impact on well-being after radiation therapy of primary brain tumours and the influence of hormone substitution - a longitudinal study

H.-M. Meinck, P. Henningsen, C. Körner, K. Dinkel, W. Richter; HEIDELBERG

55. Stiff man-syndrome, a neuropsychiatric disorder with autoimmunity against GABAergic neurones. Part I: Clinical, psychological and immunological characteristics

L.E. Miller, J. Grifka, J. Schölmerich, R.H. Straub; REGENSBURG; BAD ABBACH

56. Norepinephrine from synovial tyrosine hydroxylase positive cells is a strong indicator of synovial inflammation in rheumatoid arthritis

C. Nassenstein, J.C. Virchow Jr, S. Mayer, H. Renz, W. Luttmann, A. Braun; FREIBURG; MARBURG; HANNOVER

57. Neurotrophin-4: Evidence for a proinflammatory role in allergic asthma?

J.H. Niess, A. Dignass, A.C. Zenclussen, R. Joachim, H. Mönnikes, B.F. Klapp, P. Arck; BERLIN

60. Influence of stress on experimentally induced murine colitis

G. Pacheco-López, M. Schedlowski; ESSEN

62. Central noradrenergic depletion reduces brain c-Fos expression to a protein antigen

G. Päth, A. Braun, N. Meents, S. Kerzel, U. Raap, G.W. Hoyle, WA Nockher, H. Renz; MARBURG; HANNOVER; NEW ORLEANS

63. Allergic early-phase reaction and sensory reactivity are enhanced in transgenic mice with lung-specific overexpression of NGF

H. Rogausch, A. Del Rey, D. Zwingmann, K. Voigt, H. Besedovsky; MARBURG

66. The regulation of blood pressure is affected by an IL-1-mediated re-setting of baroreceptor reflexes at CNS levels

M. J. Schwarz, N. Müller, M. Riedel, C. Scheppach, S. Sokullu, M. Ulmschneider, R. Yolken; MUNICH; BALTIMORE

71. Are high anti - cytomegalovirus titres in schizophrenia associated with better outcome to anti-inflammatory therapy?

B. Sperner-Unterweger, S Eder, B Widner, D Fuchs; INNSBRUCK

73. Immunology and antidepressants: Modulatory effect of selective serotonin reuptake inhibitors on the human myelomonocytic cell line THP1

H. Steffen, N. Menger, H. Krastel, W. Richter and H.-M. Meinck; HEIDELBERG; FRANKFURT

75. Stiff man-syndrome, a neuropsychiatric disorder with autoimmunity against GABAergic neurones. Part III: Abnormalities in retinal function linked to autoantibodies against glutamic acid decarboxylase (GAD)

M. Stephan, T. Breivik, R.H. Straub, R. Pabst, S. von Hörsten; HANNOVER; OSLO; REGENSBURG

76. Nature-nurture interactions determine adult disease susceptibility: Stress protection as an option for the treatment of periodontal disease

U. Stockhorst, S. Hausmann, J. Wolf, P. Enck, G. Hall, S. Klosterhalfen; DÜSSELDORF; TÜBINGEN; YORK

78. Rotation-induced motion sickness in healthy humans: Subjective symptoms, cortisol, and TNF

R.H. Straub, H. Herfarth, W. Falk, J. Schölmerich, T. Andus; REGENSBURG

79. Uncoupling of the sympathetic nervous system and the hypothalamic-pituitary-adrenal-axis in inflammatory bowel disease

R.H. Straub, J.M. Kittner, C. Heijnen, M. Schedlowski, R. E. Schmidt, R. Jacobs; REGENSBURG; HANNOVER; UTRECHT; ESSEN

80. Infusion of adrenaline decreases serum levels of cortisol and 17beta-hydroxyprogesterone in patients with rheumatoid arthritis but not in healthy subjects

R.H. Straub, L. Paimela, R. Peltomaa, J. Schölmerich, M. Leirisalo-Repo; REGENSBURG; HELSINKI

81. Inadequately low serum levels of steroid hormones in relation to IL-6 and TNF in untreated patients with early rheumatoid arthritis and reactive arthritis

R.K. Stumm, J. Rummel, C. Culmsee, V. Junker, J. Krieglstein, V. Höllt, S. Schulz; MAGDEBURG; MARBURG

82. Neuronal- and endothelial-specific SDF-1 isoforms differentially modulate CXCR4-dependent neurotransmission and cerebral infiltration after focal cerebral ischaemia and peripheral immune-stimulation by LPS

L. Torner, A. Wigger, S. Krömer, I.D. Neumann; REGENSBURG; MUNICH

83. Brain neuropeptides oxytocin and prolactin: involvement in neuroendocrine and emotional stress coping strategies

M. Ulmschneider, M. Riedel, B. Brandstätter, C. Scheppach, R. Gruber, N. Müller; MUNICH

84. Immunological Effects of Celecoxib and Risperidone in the Course of a Comparative Therapy Study

C. Vogel, R. Mössner, T. Heinemann, P. Riederer, M. Gerlach, D.L. Murphy, K.-P. Lesch, C. Sommer; WÜRZBURG; BETHESDA

86. Changes of serotonin tissue concentration modulate neuropathic pain: A study in serotonin transporter-deficient mice

G. S. von Banchet, O. Schmitt, R. Bräuer, H.-G. Schaible; JENA

88. Regulation of the expression of peptide receptors on cultured DRG neurones

S. von Hörsten, S. Bedoui, H.P. Nguyen, H. Nave, A. Kask, R. Pabst; HANNOVER; TARTU

89. Models of stress protection by NPY: NPY/CRH interactions in anxiety regulation and NPY/epinephrine interactions in adrenergic leukocytosis

M. Wahle, S. Kölker, H. Häntzschel, A. Krause, C.G.O. Baerwald; LEIPZIG; HEIDELBERG; BERLIN

91. Catecholamine-induced apoptosis of B lymphocytes is reduced in patients with rheumatoid arthritis

R. Wank; MUNICH

92. Substantial improvements in three patients with bipolar, schizophrenic or autistic disorder by longterm low-dosed adoptive immunotherapy

A.C. Zenclussen, R. Joachim, C. Peiser, J. Niess, B. Klapp, P.C. Arck; BERLIN

96. Heme Oxygenase (HO) is downregulated in Stress-triggered Th1-mediated murine abortion

D. Zwingmann, H.O. Besedovsky, A. Kabiersch, H. Rogausch, A. Del Rey; MARBURG

97. Bidirectional interactions between splenic sympathetic nerves and the immune response during a graft versus host reaction

D. Zwingmann, H.O. Besedovsky, A. Kabiersch, H. Rogausch, A. Del Rey; MARBURG

98. A new denervation technique to study local noradrenergic influences on specific immune responses in popliteal lymph nodes

C. Depboylu, T.A. Reinhart, W.J. Schwaeble, H. Mitsuya, D. Rausch, L.E. Eiden, E.Weihe; MARBURG; PITTSBURGH; BETHESDA